For highly polar drugs (e.g. mannitol) what primarily determines elimination rate?
Mercapturic acid derivatives in phase II metabolism can result from reactions of:
Which of the following is an antiviral drug used in the treatment of AIDS-HIV?
I- Acyclovir
II- Zidovudine
III- Stavudine
Which of the following vitamins has tetrahydrofolate coenzyme activity based on its pteridine ring?
Which of the following compounds are considered the building blocks of nucleic acids?
Which of the following factors would be important in determining the concentration of drug that would be reached in the cerebrospinal fluid for treatment of meningitis?
I Oil/water partition coefficient
II Binding to plasma protein
III pKa of the drug
The mechanism of antipsychotic effect of phenothiazines is thought to be due to:
Cigarette smoke causes an increase in levels of CYP1A isozymes. Theophylline is primarily metabolized by the CYP1A system. What would happen to theophylline clearance for an asthmatic patient in hospital who could not smoke?
Both isoxazole and oxazole rings are found as substituents in some bacteriostatic sulfanilamides. They are present in these structures specifically because of their:
Common etiologic agents of community-acquired pneumonia include:
I Escherichia coli
II Haemophilus influenzae
III Mycoplasma pneumoniae
In an adequately powered, randomized controlled trial conducted over 3 years, a specific serious side effect (i.e. reduction in leukocytes) with conventional therapy is seen in 0.5% of the study sample. In patients who receive a newly discovered drug, only 0.45% experience the same side effect. Based on these results, the minimum number of patients that would have to receive the new drug for 3 years to statistically demonstrate the prevention of one episode of this side effect in at least one patient is:
Erythromycin:
I is effective against gram-positive cocci.
II is a macrolide antibiotic.
III can increase gastrointestinal tract motility.
Correct administration of Penicillamine in the treatment of rheumatois arthritis include:
An angiotensin-converting enzyme (ACE. inhibitor for which both renal elimination and metabolism are important in the elimination of the drug and its active metabolites is:
Examples of very narrow spectrum penicillins include all of the following, EXCEPT:
Nosocomial infections may be best treated by which of the following agents?
I- Cephalosporin 3rd generation
II- Macrolides antibiotics
III- Penicillins
Which financial statement could be used to determine the total value of prescription drug sales for a pharmacy during the course of a year?
Aerosol OT (AOT) is used in veterinary medicine as a laxative. If 250 g of AOT is dissolved in 1 000 mL of glycerin (density of glycerin is 1.25 g/mL), the concentration of AOT in the solution is:
Condition characterized by a reversible form of airflow obstruction is known as:
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TESTED 21 Nov 2024
